2'-O-methylation
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2'-O-methylation is a common nucleoside modification of RNA, where a methyl group is added to the 2' hydroxyl group of the ribose moiety of a nucleoside. 2'-O-methylated nucleosides are found in the functionally essential regions of the ribosome and spliceosome.[1] Also, 2'-O-methylation of adenosine in an RNA prevents adenosine deaminase from editing it to an inosine.[2]
See also
References
- ^ Kiss T (2001). "Small nucleolar RNA-guided post-transcriptional modification of cellular RNAs". EMBO J. 20 (14): 3617–22. doi:. http://www.nature.com/emboj/journal/v20/n14/full/7593858a.html.
- ^ Beal PA, Maydanovych O, Pokharel S (2007). [Expression error: Missing operand for > "The chemistry and biology of RNA editing by adenosine deaminases"]. Nucleic Acids Symposium Series 51 (1): 83–84. doi: .
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