1.(biochemistry) purine base found in DNA and RNA; pairs with thymine in DNA and with uracil in RNA
2.(MeSH)An enzyme catalyzing the formation of AMP from adenine and phosphoribosylpyrophosphate. It can act as a salvage enzyme for recycling of adenine into nucleic acids. EC 188.8.131.52.
Adenine Phosphoribosyltransferase (n.)
1.(MeSH)An enzyme catalyzing the formation of AMP from adenine and phosphoribosylpyrophosphate. It can act as a salvage enzyme for recycling of adenine into nucleic acids. EC 184.108.40.206.
1.(MeSH)A purine base and a fundamental unit of ADENINE NUCLEOTIDES.
definição - Wikipedia
Adenine Arabinoside • Adenine Arabinoside Monophosphate • Adenine Deoxyribonucleosides • Adenine Nucleotide Carrier (Mitochondrial) • Adenine Nucleotide Carrier Protein • Adenine Nucleotide Translocator 1 • Adenine Nucleotide Translocator 2 • Adenine Nucleotide Translocator 3 • Adenine Nucleotide Translocator), Member 4 • Adenine Nucleotide Translocator), Member 5 • Adenine Nucleotide Translocator), Member 6 • Adenine Nucleotide Translocator, Fibroblast Isoform • Adenine Nucleotide Translocator, Muscle Isoform • Adenine Nucleotides • DNA-Adenine Methylases • Flavin-Adenine Dinucleotide • nicotinamide adenine dinucleotide • nicotinamide adenine dinucleotide phosphate • nicotinamide-adenine-dinucleotide • nicotinamide-adenine-dinucleotide phosphate
Adenine (programming language) • Adenine deaminase • Adenine nucleotide translocator • Adenine pathway • Adenine phosphoribosyltransferase • Adenine phosphoribosyltransferase deficiency • Dna adenine methylase • Flavin adenine dinucleotide • Nicotinamide adenine dinucleotide phosphate • Nicotinic acid adenine dinucleotide phosphate • RRNA (adenine-N6-)-methyltransferase • TRNA (adenine-N1-)-methyltransferase • TRNA (adenine-N6-)-methyltransferase
dérivé de l'azote (fr)[Classe]
composé minéral (fr)[Classe...]
partie de cellule vivante (fr)[Classe...]
composé azoté (fr)[Classe]
acide nucléique (fr)[Classe]
chemistry; chemical science[Classe]
biology; biological science[Classe]
noyau de la cellule (fr)[DomainDescrip.]
composé azoté (fr)[ClasseParExt.]
noyau de la cellule (fr)[DomainDescrip.]
adenine (n.) [MeSH]
|Jmol-3D images||Image 1
|Molar mass||135.13 g/mol|
|Density||1.6 g/cm3 (calculated)|
360–365 °C (decomposes)
|Acidity (pKa)||4.15 (secondary), 9.80 (primary)|
| (what is: / ?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Adenine (A, Ade) is a nucleobase (a purine derivative) with a variety of roles in biochemistry including cellular respiration, in the form of both the energy-rich adenosine triphosphate (ATP) and the cofactors nicotinamide adenine dinucleotide (NAD) and flavin adenine dinucleotide (FAD), and protein synthesis, as a chemical component of DNA and RNA. The shape of adenine is complementary to either thymine in DNA or uracil in RNA.
Adenine forms several tautomers, compounds that can be rapidly interconverted and are often considered equivalent. However, in isolated conditions, i.e. in an inert gas matrix and in the gas phase, mainly the 9H-adenine tautomer is found.
Purine metabolism involves the formation of adenine and guanine. Both adenine and guanine are derived from the nucleotide inosine monophosphate (IMP), which is synthesised on a pre-existing ribose phosphate through a complex pathway using atoms from the amino acids glycine, glutamine, and aspartic acid, as well as fused with the enzyme tetrahydrofolate.
Adenine is one of the two purine nucleobases (the other being guanine) used in forming nucleotides of the nucleic acids. In DNA, adenine binds to thymine via two hydrogen bonds to assist in stabilizing the nucleic acid structures. In RNA, which is used for protein synthesis, adenine binds to uracil.
Adenine forms adenosine, a nucleoside, when attached to ribose, and deoxyadenosine when attached to deoxyribose. It forms adenosine triphosphate (ATP), a nucleotide, when three phosphate groups are added to adenosine. Adenosine triphosphate is used in cellular metabolism as one of the basic methods of transferring chemical energy between chemical reactions.
In older literature, adenine was sometimes called Vitamin B4. It is no longer considered a true vitamin or part of the Vitamin B complex. However, two B vitamins, niacin and riboflavin, bind with adenine to form the essential cofactors nicotinamide adenine dinucleotide (NAD) and flavin adenine dinucleotide (FAD), respectively. Hermann Emil Fischer was one of the early scientists to study adenine.
Experiments performed in 1961 by Joan Oró have shown that a large quantity of adenine can be synthesized from the polymerization of ammonia with five hydrogen cyanide (HCN) molecules in aqueous solution; whether this has implications for the origin of life on Earth is under debate.
On August 8, 2011, a report, based on NASA studies with meteorites found on Earth, was published suggesting building blocks of DNA and RNA (adenine, guanine and related organic molecules) may have been formed extraterrestrially in outer space. In 2011, physicists reported that adenine has an "unexpectedly variable range of ionization energies along its reaction pathways" which suggested that "understanding experimental data on how adenine survives exposure to UV light is much more complicated than previously thought"; these findings have implications for spectroscopic measurements of heterocyclic compounds, according to one report.
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