Definição e significado de Calcium Carbimide

Calcium carbimide

Systematic (IUPAC) name
calcium 2-hydroxypropane-1,2,3-tricarboxylate; methylcyanamide
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	8013-88-5 Y
ATC code	N07BB02
PubChem	CID 6335910
ChemSpider	21106422 Y
UNII	ZLR270912W N
Chemical data
Formula	C6H8O7.CH2N2.Ca
Mol. mass	288.268 g/mol
SMILES [Ca+2].O=C([O-])CC(O)(CC(=O)O)C([O-])=O.N#CNC
InChI InChI=1S/C6H8O7.C2H4N2.Ca/c7-3(8)1-6(13,5(11)12)2-4(9)10;1-4-2-3;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);4H,1H3;/q;;+2/p-2 Y Key:ZZOBQLACMMNMCT-UHFFFAOYSA-L Y
N (what is this?)  (verify)

Calcium carbimide, sold as the citrate salt under the trade name Temposil, is an alcohol sensitizing agent. Its effects are similar to the drug disulfiram (Antabuse) in that it interferes with the normal metabolism of alcohol by preventing the breakdown of the metabolic byproduct acetaldehyde. The result is that when alcohol is consumed by users of calcium carbimide, they experience severe reactions which include symptoms such as sweating, difficulty breathing, rapid heartbeat, rash, nausea and vomiting, and headache.

A recent 9-year study found that incorporation of supervised carbimide and the similar drug, disulfiram, into a comprehensive treatment program resulted in an abstinence rate of over 50%.^[1]

  References

1. ^ Krampe H, Stawicki S, Wagner T, et al. (January 2006). "Follow-up of 180 alcoholic patients for up to 7 years after outpatient treatment: impact of alcohol deterrents on outcome". Alcoholism, clinical and experimental research 30 (1): 86–95. DOI:10.1111/j.1530-0277.2006.00013.x. ISSN 0145-6008. PMID 16433735.