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Definição e significado de EIF1AX

Definição

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EIF1AX

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Eukaryotic translation initiation factor 1A, X-linked

PDB rendering based on 1d7q.
Available structures
1d7q
Identifiers
SymbolsEIF1AX; EIF1A; EIF4C; eIF-1A; eIF-4C
External IDsOMIM300186 MGI1913485 HomoloGene20364 GeneCards: EIF1AX Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez196466235
EnsemblENSG00000173674n/a
UniProtO75642n/a
RefSeq (mRNA)XM_001134077NM_025437
RefSeq (protein)XP_001134077NP_079713
Location (UCSC)Chr X:
20.05 - 20.07 Mb
n/a
PubMed search[1][2]

Eukaryotic translation initiation factor 1A, X-chromosomal is a protein that in humans is encoded by the EIF1AX gene.[1][2][3]

This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA.[3]

Interactions

EIF1AX has been shown to interact with IPO13.[4]

References

  1. ^ Dever TE, Wei CL, Benkowski LA, Browning K, Merrick WC, Hershey JW (Mar 1994). [Expression error: Missing operand for > "Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing"]. J Biol Chem 269 (5): 3212–8. PMID 8106356. 
  2. ^ Lahn BT, Page DC (Nov 1997). [Expression error: Missing operand for > "Functional coherence of the human Y chromosome"]. Science 278 (5338): 675–80. PMID 9381176. 
  3. ^ a b "Entrez Gene: EIF1AX eukaryotic translation initiation factor 1A, X-linked". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1964. 
  4. ^ Mingot, J M; Kostka S, Kraft R, Hartmann E, Görlich D (Jul. 2001). [Expression error: Missing operand for > "Importin 13: a novel mediator of nuclear import and export"]. EMBO J. (England) 20 (14): 3685–94. doi:10.1093/emboj/20.14.3685. ISSN 0261-4189. PMID 11447110. 

Further reading

  • Battiste JL, Pestova TV, Hellen CU, Wagner G (2000). [Expression error: Missing operand for > "The eIF1A solution structure reveals a large RNA-binding surface important for scanning function."]. Mol. Cell 5 (1): 109–19. doi:10.1016/S1097-2765(00)80407-4. PMID 10678173. 
  • Choi SK, Olsen DS, Roll-Mecak A, et al. (2000). [Expression error: Missing operand for > "Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2."]. Mol. Cell. Biol. 20 (19): 7183–91. doi:10.1128/MCB.20.19.7183-7191.2000. PMID 10982835. 
  • Mingot JM, Kostka S, Kraft R, et al. (2001). [Expression error: Missing operand for > "Importin 13: a novel mediator of nuclear import and export."]. Embo J. 20 (14): 3685–94. doi:10.1093/emboj/20.14.3685. PMID 11447110. 
  • Sørensen HP, Hedegaard J, Sperling-Petersen HU, Mortensen KK (2002). [Expression error: Missing operand for > "Remarkable conservation of translation initiation factors: IF1/eIF1A and IF2/eIF5B are universally distributed phylogenetic markers."]. IUBMB Life 51 (5): 321–7. doi:10.1080/152165401317190842. PMID 11699879. 
  • Bohnsack MT, Regener K, Schwappach B, et al. (2003). [Expression error: Missing operand for > "Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm."]. Embo J. 21 (22): 6205–15. doi:10.1093/emboj/cdf613. PMID 12426392. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Olsen DS, Savner EM, Mathew A, et al. (2003). [Expression error: Missing operand for > "Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo."]. Embo J. 22 (2): 193–204. doi:10.1093/emboj/cdg030. PMID 12514125. 
  • Marintchev A, Kolupaeva VG, Pestova TV, Wagner G (2003). [Expression error: Missing operand for > "Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners."]. Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1535–40. doi:10.1073/pnas.0437845100. PMID 12569173. 
  • Agate RJ, Choe M, Arnold AP (2004). [Expression error: Missing operand for > "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches."]. Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). [Expression error: Missing operand for > "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."]. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). [Expression error: Missing operand for > "The DNA sequence of the human X chromosome."]. Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). [Expression error: Missing operand for > "Towards a proteome-scale map of the human protein-protein interaction network."]. Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). [Expression error: Missing operand for > "The DNA sequence and biological annotation of human chromosome 1."]. Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
  • Kim S, Kim GJ, Miyoshi H, et al. (2007). [Expression error: Missing operand for > "Efficiency of the elongation factor-1alpha promoter in mammalian embryonic stem cells using lentiviral gene delivery systems."]. Stem Cells Dev. 16 (4): 537–45. doi:10.1089/scd.2006.0088. PMID 17784828. 

 

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