From Wikipedia, the free encyclopedia
Eukaryotic translation initiation factor 1A, X-chromosomal is a protein that in humans is encoded by the EIF1AX gene.[1][2][3]
This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA.[3]
Interactions
EIF1AX has been shown to interact with IPO13.[4]
References
- ^ Dever TE, Wei CL, Benkowski LA, Browning K, Merrick WC, Hershey JW (Mar 1994). [Expression error: Missing operand for > "Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing"]. J Biol Chem 269 (5): 3212–8. PMID 8106356.
- ^ Lahn BT, Page DC (Nov 1997). [Expression error: Missing operand for > "Functional coherence of the human Y chromosome"]. Science 278 (5338): 675–80. PMID 9381176.
- ^ a b "Entrez Gene: EIF1AX eukaryotic translation initiation factor 1A, X-linked". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1964.
- ^ Mingot, J M; Kostka S, Kraft R, Hartmann E, Görlich D (Jul. 2001). [Expression error: Missing operand for > "Importin 13: a novel mediator of nuclear import and export"]. EMBO J. (England) 20 (14): 3685–94. doi:10.1093/emboj/20.14.3685. ISSN 0261-4189. PMID 11447110.
Further reading
- Battiste JL, Pestova TV, Hellen CU, Wagner G (2000). [Expression error: Missing operand for > "The eIF1A solution structure reveals a large RNA-binding surface important for scanning function."]. Mol. Cell 5 (1): 109–19. doi:10.1016/S1097-2765(00)80407-4. PMID 10678173.
- Choi SK, Olsen DS, Roll-Mecak A, et al. (2000). [Expression error: Missing operand for > "Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2."]. Mol. Cell. Biol. 20 (19): 7183–91. doi:10.1128/MCB.20.19.7183-7191.2000. PMID 10982835.
- Mingot JM, Kostka S, Kraft R, et al. (2001). [Expression error: Missing operand for > "Importin 13: a novel mediator of nuclear import and export."]. Embo J. 20 (14): 3685–94. doi:10.1093/emboj/20.14.3685. PMID 11447110.
- Sørensen HP, Hedegaard J, Sperling-Petersen HU, Mortensen KK (2002). [Expression error: Missing operand for > "Remarkable conservation of translation initiation factors: IF1/eIF1A and IF2/eIF5B are universally distributed phylogenetic markers."]. IUBMB Life 51 (5): 321–7. doi:10.1080/152165401317190842. PMID 11699879.
- Bohnsack MT, Regener K, Schwappach B, et al. (2003). [Expression error: Missing operand for > "Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm."]. Embo J. 21 (22): 6205–15. doi:10.1093/emboj/cdf613. PMID 12426392.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Olsen DS, Savner EM, Mathew A, et al. (2003). [Expression error: Missing operand for > "Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo."]. Embo J. 22 (2): 193–204. doi:10.1093/emboj/cdg030. PMID 12514125.
- Marintchev A, Kolupaeva VG, Pestova TV, Wagner G (2003). [Expression error: Missing operand for > "Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners."]. Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1535–40. doi:10.1073/pnas.0437845100. PMID 12569173.
- Agate RJ, Choe M, Arnold AP (2004). [Expression error: Missing operand for > "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches."]. Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). [Expression error: Missing operand for > "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."]. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). [Expression error: Missing operand for > "The DNA sequence of the human X chromosome."]. Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
- Rual JF, Venkatesan K, Hao T, et al. (2005). [Expression error: Missing operand for > "Towards a proteome-scale map of the human protein-protein interaction network."]. Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). [Expression error: Missing operand for > "The DNA sequence and biological annotation of human chromosome 1."]. Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Kim S, Kim GJ, Miyoshi H, et al. (2007). [Expression error: Missing operand for > "Efficiency of the elongation factor-1alpha promoter in mammalian embryonic stem cells using lentiviral gene delivery systems."]. Stem Cells Dev. 16 (4): 537–45. doi:10.1089/scd.2006.0088. PMID 17784828.
PDB Gallery |
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| 1d7q: HUMAN TRANSLATION INITIATION FACTOR EIF1A |
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Protein biosynthesis: translation (prokaryotic, eukaryotic) |
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Ribosomal proteins | | | | |
Archaeal | aIF1 aIF2 aIF5 aIF6 | |
| eIF1 (AX, AY, 1B) eIF2 (α, β, γ) eIF3 (A, B, C, D, F, G, H, I, J, K, M, S6) eIF4 (A2, A3, B, E1, E2, G1, G2, G3, H) eIF5 (A, A2, B) eIF6 |
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Other | |
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Other concepts | |
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