definição e significado de EIF2S2

EIF2S2

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Eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa

Identifiers

Symbols

EIF2S2; EIF2; EIF2B; DKFZp686L18198; EIF2beta; MGC8508

External IDs

OMIM: 603908 MGI: 1914454 HomoloGene: 2904 GeneCards: EIF2S2 Gene

Gene ontology
Molecular function	• RNA binding • translation initiation factor activity • zinc ion binding • metal ion binding
Cellular component	• ribosome • eukaryotic translation initiation factor 2 complex
Biological process	• translational initiation

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 20:
32.14 - 32.16 Mb

Chr 8:
53.69 - 53.7 Mb

PubMed search

[1]

[2]

Eukaryotic translation initiation factor 2 subunit 2 is a protein that in humans is encoded by the EIF2S2 gene.^[1]^[2]^[1]

1 Function
2 Regulation
3 See also
4 References
5 Further reading

Function

Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta (this article), and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation.^[2]

Regulation

Both eIF2-alpha and eIF2-beta expression is regulated by the the NRF1 transcription factor.^[3]

References

^ ^a ^b Pathak VK, Nielsen PJ, Trachsel H, Hershey JW (Sep 1988). [Expression error: Missing operand for > "Structure of the beta subunit of translational initiation factor eIF-2"]. Cell 54 (5): 633-9. PMID 3044606.
^ ^a ^b "Entrez Gene: EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8894.
^ Chiorini JA, Miyamoto S, Harkin SJ, Safer B (February 1999). [Expression error: Missing operand for > "Genomic cloning and characterization of the human eukaryotic initiation factor-2beta promoter"]. J. Biol. Chem. 274 (7): 4195–201. doi:10.1074/jbc.274.7.4195. PMID 9933616.

Welsh GI, Price NT, Bladergroen BA, et al. (1994). [Expression error: Missing operand for > "Identification of novel phosphorylation sites in the beta-subunit of translation initiation factor eIF-2."]. Biochem. Biophys. Res. Commun. 201 (3): 1279–88. doi:10.1006/bbrc.1994.1843. PMID 8024572.
Brand SR, Kobayashi R, Mathews MB (1997). [Expression error: Missing operand for > "The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR."]. J. Biol. Chem. 272 (13): 8388–95. doi:10.1074/jbc.272.13.8388. PMID 9079663.
Das S, Maiti T, Das K, Maitra U (1998). [Expression error: Missing operand for > "Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2."]. J. Biol. Chem. 272 (50): 31712–8. doi:10.1074/jbc.272.50.31712. PMID 9395514.
Ting NS, Kao PN, Chan DW, et al. (1998). [Expression error: Missing operand for > "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45."]. J. Biol. Chem. 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054.
Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS (1998). [Expression error: Missing operand for > "Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B."]. J. Biol. Chem. 273 (5): 3039–44. doi:10.1074/jbc.273.5.3039. PMID 9446619.
Chiorini JA, Miyamoto S, Harkin SJ, Safer B (1999). [Expression error: Missing operand for > "Genomic cloning and characterization of the human eukaryotic initiation factor-2beta promoter."]. J. Biol. Chem. 274 (7): 4195–201. doi:10.1074/jbc.274.7.4195. PMID 9933616.
Cai R, Carpick B, Chun RF, et al. (2000). [Expression error: Missing operand for > "HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms."]. Arch. Biochem. Biophys. 373 (2): 361–7. doi:10.1006/abbi.1999.1583. PMID 10620360.
Ben-Asouli Y, Banai Y, Hauser H, Kaempfer R (2000). [Expression error: Missing operand for > "Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2."]. Nucleic Acids Res. 28 (4): 1011–8. doi:10.1093/nar/28.4.1011. PMID 10648795.
Das S, Maitra U (2000). [Expression error: Missing operand for > "Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo."]. Mol. Cell. Biol. 20 (11): 3942–50. doi:10.1128/MCB.20.11.3942-3950.2000. PMID 10805737.
Gomez E, Pavitt GD (2000). [Expression error: Missing operand for > "Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation."]. Mol. Cell. Biol. 20 (11): 3965–76. doi:10.1128/MCB.20.11.3965-3976.2000. PMID 10805739.
Das S, Ghosh R, Maitra U (2001). [Expression error: Missing operand for > "Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein."]. J. Biol. Chem. 276 (9): 6720–6. doi:10.1074/jbc.M008863200. PMID 11092890.
Reichman TW, Muñiz LC, Mathews MB (2002). [Expression error: Missing operand for > "The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells."]. Mol. Cell. Biol. 22 (1): 343–56. doi:10.1128/MCB.22.1.343-356.2002. PMID 11739746.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). [Expression error: Missing operand for > "The DNA sequence and comparative analysis of human chromosome 20."]. Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Kebache S, Zuo D, Chevet E, Larose L (2002). [Expression error: Missing operand for > "Modulation of protein translation by Nck-1."]. Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5406–11. doi:10.1073/pnas.082483399. PMID 11959995.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Llorens F, Roher N, Miró FA, et al. (2004). [Expression error: Missing operand for > "Eukaryotic translation-initiation factor eIF2beta binds to protein kinase CK2: effects on CK2alpha activity."]. Biochem. J. 375 (Pt 3): 623–31. doi:10.1042/BJ20030915. PMID 12901717.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). [Expression error: Missing operand for > "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."]. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). [Expression error: Missing operand for > "Nucleolar proteome dynamics."]. Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Stelzl U, Worm U, Lalowski M, et al. (2005). [Expression error: Missing operand for > "A human protein-protein interaction network: a resource for annotating the proteome."]. Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

Protein biosynthesis: translation (prokaryotic, eukaryotic)

Ribosomal proteins

Initiation factor

Prokaryotic	PIF-1 · PIF-2 · PIF-3
Archaeal	aIF1 aIF2 aIF5 aIF6
Eukaryotic	eIF1 (AX, AY, 1B) eIF2 (α, β, γ) eIF3 (A, B, C, D, F, G, H, I, J, K, M, S6) eIF4 (A2, A3, B, E1, E2, G1, G2, G3, H) eIF5 (A, A2, B) eIF6