From Wikipedia, the free encyclopedia
Eukaryotic translation initiation factor 2 subunit 3 is a protein that in humans is encoded by the EIF2S3 gene.[1][2][3][1][2]
Function
Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma (this article), with the protein encoded by this gene representing the gamma subunit.[3]
See also
References
- ^ a b Gaspar NJ, Kinzy TG, Scherer BJ, Humbelin M, Hershey JW, Merrick WC (Mar 1994). [Expression error: Missing operand for > "Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit"]. J Biol Chem 269 (5): 3415-22. PMID 8106381.
- ^ a b Ehrmann IE, Ellis PS, Mazeyrat S, Duthie S, Brockdorff N, Mattei MG, Gavin MA, Affara NA, Brown GM, Simpson E, Mitchell MJ, Scott DM (Dec 1998). [Expression error: Missing operand for > "Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution"]. Hum Mol Genet 7 (11): 1725-37. PMID 9736774.
- ^ a b "Entrez Gene: EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1968.
Further reading
- Ray MK, Chakraborty A, Datta B, et al. (1993). [Expression error: Missing operand for > "Characteristics of the eukaryotic initiation factor 2 associated 67-kDa polypeptide."]. Biochemistry 32 (19): 5151–9. doi:10.1021/bi00070a026. PMID 8098621.
- Maruyama K, Sugano S (1994). [Expression error: Missing operand for > "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides."]. Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Brand SR, Kobayashi R, Mathews MB (1997). [Expression error: Missing operand for > "The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR."]. J. Biol. Chem. 272 (13): 8388–95. doi:10.1074/jbc.272.13.8388. PMID 9079663.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). [Expression error: Missing operand for > "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library."]. Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Cai R, Carpick B, Chun RF, et al. (2000). [Expression error: Missing operand for > "HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms."]. Arch. Biochem. Biophys. 373 (2): 361–7. doi:10.1006/abbi.1999.1583. PMID 10620360.
- Ben-Asouli Y, Banai Y, Hauser H, Kaempfer R (2000). [Expression error: Missing operand for > "Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2."]. Nucleic Acids Res. 28 (4): 1011–8. doi:10.1093/nar/28.4.1011. PMID 10648795.
- Kruger M, Beger C, Li QX, et al. (2000). [Expression error: Missing operand for > "Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach."]. Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8566–71. doi:10.1073/pnas.97.15.8566. PMID 10900014.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Gevaert K, Goethals M, Martens L, et al. (2004). [Expression error: Missing operand for > "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."]. Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). [Expression error: Missing operand for > "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."]. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Andersen JS, Lam YW, Leung AK, et al. (2005). [Expression error: Missing operand for > "Nucleolar proteome dynamics."]. Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Filippova GN, Cheng MK, Moore JM, et al. (2005). [Expression error: Missing operand for > "Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development."]. Dev. Cell 8 (1): 31–42. doi:10.1016/j.devcel.2004.10.018. PMID 15669143.
- Marques AC, Dupanloup I, Vinckenbosch N, et al. (2006). [Expression error: Missing operand for > "Emergence of young human genes after a burst of retroposition in primates."]. PLoS Biol. 3 (11): e357. doi:10.1371/journal.pbio.0030357. PMID 16201836.
- Suragani RN, Kamindla R, Ehtesham NZ, Ramaiah KV (2006). [Expression error: Missing operand for > "Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases."]. Biochem. Biophys. Res. Commun. 338 (4): 1766–72. doi:10.1016/j.bbrc.2005.10.150. PMID 16288713.
- Mikami S, Masutani M, Sonenberg N, et al. (2006). [Expression error: Missing operand for > "An efficient mammalian cell-free translation system supplemented with translation factors."]. Protein Expr. Purif. 46 (2): 348–57. doi:10.1016/j.pep.2005.09.021. PMID 16289705.
- Tu LC, Yan X, Hood L, Lin B (2007). [Expression error: Missing operand for > "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells."]. Mol. Cell Proteomics 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.
- Ewing RM, Chu P, Elisma F, et al. (2007). [Expression error: Missing operand for > "Large-scale mapping of human protein-protein interactions by mass spectrometry."]. Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
| Protein biosynthesis: translation (prokaryotic, eukaryotic) |
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| Ribosomal proteins | | | | |
Archaeal | aIF1 aIF2 aIF5 aIF6 | |
| eIF1 (AX, AY, 1B) eIF2 (α, β, γ) eIF3 (A, B, C, D, F, G, H, I, J, K, M, S6) eIF4 (A2, A3, B, E1, E2, G1, G2, G3, H) eIF5 (A, A2, B) eIF6 |
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Other | |
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| Other concepts | |
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