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alemão búlgaro chinês croata dinamarquês eslovaco esloveno espanhol estoniano farsi finlandês francês grego hebraico hindi holandês húngaro indonésio inglês islandês italiano japonês korean letão língua árabe lituano malgaxe norueguês polonês português romeno russo sérvio sueco tailandês tcheco turco vietnamês

Definição e significado de EIF4E2

Definição

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EIF4E2

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Eukaryotic translation initiation factor 4E family member 2

PDB rendering based on 2jgb.
Available structures
2jgb, 2jgc
Identifiers
SymbolsEIF4E2; 4E-LP; 4EHP; EIF4EL3; IF4e
External IDsOMIM605895 MGI1914440 HomoloGene31268 GeneCards: EIF4E2 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez947026987
EnsemblENSG00000135930ENSMUSG00000026254
UniProtO60573Q0P688
RefSeq (mRNA)NM_004846NM_001039169
RefSeq (protein)NP_004837NP_001034258
Location (UCSC)Chr 2:
233.12 - 233.16 Mb
Chr 1:
89.05 - 89.07 Mb
PubMed search[1][2]

Eukaryotic translation initiation factor 4E type 2 is a protein that in humans is encoded by the EIF4E2 gene.[1][2][3]


Interactions

EIF4E2 has been shown to interact with ARIH1.[4]

References

  1. ^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). [Expression error: Missing operand for > "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning"]. Proc Natl Acad Sci U S A 95 (14): 8175–80. PMID 9653160. 
  2. ^ Rom E, Kim HC, Gingras AC, Marcotrigiano J, Favre D, Olsen H, Burley SK, Sonenberg N (Jun 1998). [Expression error: Missing operand for > "Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein"]. J Biol Chem 273 (21): 13104–9. PMID 9582349. 
  3. ^ "Entrez Gene: EIF4E2 eukaryotic translation initiation factor 4E family member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9470. 
  4. ^ Tan, Nancy G S; Ardley Helen C, Scott Gina B, Rose Stephen A, Markham Alexander F, Robinson Philip A (Nov. 2003). [Expression error: Missing operand for > "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP"]. FEBS Lett. (Netherlands) 554 (3): 501–4. ISSN 0014-5793. PMID 14623119. 

Further reading

  • Zhang QH, Ye M, Wu XY, et al. (2001). [Expression error: Missing operand for > "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."]. Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMID 11042152. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Tan NG, Ardley HC, Scott GB, et al. (2003). [Expression error: Missing operand for > "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP."]. FEBS Lett. 554 (3): 501–4. doi:10.1016/S0014-5793(03)01235-3. PMID 14623119. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). [Expression error: Missing operand for > "Complete sequencing and characterization of 21,243 full-length human cDNAs."]. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Tee AR, Tee JA, Blenis J (2004). [Expression error: Missing operand for > "Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1."]. FEBS Lett. 564 (1-2): 58–62. doi:10.1016/S0014-5793(04)00313-8. PMID 15094042. 
  • Joshi B, Cameron A, Jagus R (2004). [Expression error: Missing operand for > "Characterization of mammalian eIF4E-family members."]. Eur. J. Biochem. 271 (11): 2189–203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). [Expression error: Missing operand for > "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."]. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). [Expression error: Missing operand for > "Towards a proteome-scale map of the human protein-protein interaction network."]. Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Okumura F, Zou W, Zhang DE (2007). [Expression error: Missing operand for > "ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP."]. Genes Dev. 21 (3): 255–60. doi:10.1101/gad.1521607. PMID 17289916. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). [Expression error: Missing operand for > "Large-scale mapping of human protein-protein interactions by mass spectrometry."]. Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
  • Rosettani P, Knapp S, Vismara MG, et al. (2007). [Expression error: Missing operand for > "Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms."]. J. Mol. Biol. 368 (3): 691–705. doi:10.1016/j.jmb.2007.02.019. PMID 17368478. 
  • Zuberek J, Kubacka D, Jablonowska A, et al. (2007). [Expression error: Missing operand for > "Weak binding affinity of human 4EHP for mRNA cap analogs."]. RNA 13 (5): 691–7. doi:10.1261/rna.453107. PMID 17369309. 

 

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