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alemão búlgaro chinês croata dinamarquês eslovaco esloveno espanhol estoniano farsi finlandês francês grego hebraico hindi holandês húngaro indonésio inglês islandês italiano japonês korean letão língua árabe lituano malgaxe norueguês polonês português romeno russo sérvio sueco tailandês tcheco turco vietnamês

Definição e significado de MCM2

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MCM2

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MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)
Identifiers
SymbolsMCM2; BM28; CCNL1; CDCL1; D3S3194; KIAA0030; MGC10606; MITOTIN; cdc19
External IDsOMIM116945 MGI105380 HomoloGene3325 GeneCards: MCM2 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez417117216
EnsemblENSG00000073111ENSMUSG00000002870
UniProtP49736Q3UJN1
RefSeq (mRNA)NM_004526NM_008564
RefSeq (protein)NP_004517NP_032590
Location (UCSC)Chr 3:
128.8 - 128.82 Mb
Chr 6:
88.85 - 88.86 Mb
PubMed search[1][2]

DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.[1][2]

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.[3]

Contents

See also

Interactions

MCM2 has been shown to interact with Replication protein A1,[4] AKAP8,[5] MCM5,[4][6] MCM6,[7][8][4][9][10] MCM7,[8][4][9][11][10] ORC1L,[4] ORC2L,[4] ORC4L,[4] ORC5L,[4] MCM4,[8][4][9][12] MCM3[4] and Cell division cycle 7-related protein kinase.[4]

References

  1. ^ Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V (Jul 1991). [Expression error: Missing operand for > "Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle"]. Biochem Biophys Res Commun 177 (1): 395–400. PMID 1710453. 
  2. ^ Mincheva A, Todorov I, Werner D, Fink TM, Lichter P (Jan 1994). [Expression error: Missing operand for > "The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21"]. Cytogenet Cell Genet 65 (4): 276–7. PMID 8258304. 
  3. ^ "Entrez Gene: MCM2 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4171. 
  4. ^ a b c d e f g h i j k Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (Mar. 2003). [Expression error: Missing operand for > "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells"]. J. Mol. Biol. (England) 327 (1): 111–28. ISSN 0022-2836. PMID 12614612. 
  5. ^ Eide, Turid; Taskén Kristin A, Carlson Cathrine, Williams Gareth, Jahnsen Tore, Taskén Kjetil, Collas Philippe (Jul. 2003). [Expression error: Missing operand for > "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication"]. J. Biol. Chem. (United States) 278 (29): 26750–6. doi:10.1074/jbc.M300765200. ISSN 0021-9258. PMID 12740381. 
  6. ^ DaFonseca, C J; Shu F, Zhang J J (Mar. 2001). [Expression error: Missing operand for > "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma"]. Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (6): 3034–9. doi:10.1073/pnas.061487598. ISSN 0027-8424. PMID 11248027. 
  7. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). [Expression error: Missing operand for > "Towards a proteome-scale map of the human protein-protein interaction network"]. Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  8. ^ a b c Yabuta, Norikazu; Kajimura Naoko, Mayanagi Kouta, Sato Michio, Gotow Takahito, Uchiyama Yasuo, Ishimi Yukio, Nojima Hiroshi (May. 2003). [Expression error: Missing operand for > "Mammalian Mcm2/4/6/7 complex forms a toroidal structure"]. Genes Cells (England) 8 (5): 413–21. ISSN 1356-9597. PMID 12694531. 
  9. ^ a b c You, Z; Komamura Y, Ishimi Y (Dec. 1999). [Expression error: Missing operand for > "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity"]. Mol. Cell. Biol. (UNITED STATES) 19 (12): 8003–15. ISSN 0270-7306. PMID 10567526. 
  10. ^ a b You, Zhiying; Ishimi Yukio, Masai Hisao, Hanaoka Fumio (Nov. 2002). [Expression error: Missing operand for > "Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex"]. J. Biol. Chem. (United States) 277 (45): 42471–9. doi:10.1074/jbc.M205769200. ISSN 0021-9258. PMID 12207017. 
  11. ^ Fujita, M; Kiyono T, Hayashi Y, Ishibashi M (Apr. 1997). [Expression error: Missing operand for > "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP"]. J. Biol. Chem. (UNITED STATES) 272 (16): 10928–35. ISSN 0021-9258. PMID 9099751. 
  12. ^ Ishimi, Y; Ichinose S, Omori A, Sato K, Kimura H (Sep. 1996). [Expression error: Missing operand for > "Binding of human minichromosome maintenance proteins with histone H3"]. J. Biol. Chem. (UNITED STATES) 271 (39): 24115–22. ISSN 0021-9258. PMID 8798650. 

Further reading

  • Nomura N, Miyajima N, Sazuka T, et al. (1995). [Expression error: Missing operand for > "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."]. DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026. 
  • Nomura N, Miyajima N, Sazuka T, et al. (1995). [Expression error: Missing operand for > "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)."]. DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028. 
  • Nakatsuru S, Sudo K, Nakamura Y (1995). [Expression error: Missing operand for > "Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication."]. Cytogenet. Cell Genet. 68 (3-4): 226–30. doi:10.1159/000133918. PMID 7842741. 
  • Todorov IT, Pepperkok R, Philipova RN, et al. (1994). [Expression error: Missing operand for > "A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division."]. J. Cell. Sci. 107 ( Pt 1): 253–65. PMID 8175912. 
  • Ishimi Y, Ichinose S, Omori A, et al. (1996). [Expression error: Missing operand for > "Binding of human minichromosome maintenance proteins with histone H3."]. J. Biol. Chem. 271 (39): 24115–22. doi:10.1074/jbc.271.39.24115. PMID 8798650. 
  • Fujita M, Yamada C, Tsurumi T, et al. (1998). [Expression error: Missing operand for > "Cell cycle- and chromatin binding state-dependent phosphorylation of human MCM heterohexameric complexes. A role for cdc2 kinase."]. J. Biol. Chem. 273 (27): 17095–101. doi:10.1074/jbc.273.27.17095. PMID 9642275. 
  • Jiang W, McDonald D, Hope TJ, Hunter T (1999). [Expression error: Missing operand for > "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication."]. Embo J. 18 (20): 5703–13. doi:10.1093/emboj/18.20.5703. PMID 10523313. 
  • You Z, Komamura Y, Ishimi Y (2000). [Expression error: Missing operand for > "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity."]. Mol. Cell. Biol. 19 (12): 8003–15. PMID 10567526. 
  • Ishimi Y, Komamura-Kohno Y, You Z, et al. (2000). [Expression error: Missing operand for > "Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2."]. J. Biol. Chem. 275 (21): 16235–41. doi:10.1074/jbc.M909040199. PMID 10748114. 
  • Masai H, Matsui E, You Z, et al. (2000). [Expression error: Missing operand for > "Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks."]. J. Biol. Chem. 275 (37): 29042–52. doi:10.1074/jbc.M002713200. PMID 10846177. 
  • Izumi M, Yanagi K, Mizuno T, et al. (2001). [Expression error: Missing operand for > "The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase."]. Nucleic Acids Res. 28 (23): 4769–77. doi:10.1093/nar/28.23.4769. PMID 11095689. 
  • Burke TW, Cook JG, Asano M, Nevins JR (2001). [Expression error: Missing operand for > "Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1."]. J. Biol. Chem. 276 (18): 15397–408. doi:10.1074/jbc.M011556200. PMID 11278932. 
  • Tan DF, Huberman JA, Hyland A, et al. (2002). [Expression error: Missing operand for > "MCM2--a promising marker for premalignant lesions of the lung: a cohort study."]. BMC Cancer 1: 6. doi:10.1186/1471-2407-1-6. PMID 11472637. 
  • Ishimi Y, Komamura-Kohno Y, Arai K, Masai H (2001). [Expression error: Missing operand for > "Biochemical activities associated with mouse Mcm2 protein."]. J. Biol. Chem. 276 (46): 42744–52. doi:10.1074/jbc.M106861200. PMID 11568184. 
  • Wohlschlegel JA, Dhar SK, Prokhorova TA, et al. (2002). [Expression error: Missing operand for > "Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45."]. Mol. Cell 9 (2): 233–40. doi:10.1016/S1097-2765(02)00456-2. PMID 11864598. 
  • Kodani I, Shomori K, Osaki M, et al. (2002). [Expression error: Missing operand for > "Expression of minichromosome maintenance 2 (MCM2), Ki-67, and cell-cycle-related molecules, and apoptosis in the normal-dysplasia-carcinoma sequence of the oral mucosa."]. Pathobiology 69 (3): 150–8. doi:10.1159/000048770. PMID 11872961. 
  • Edwards MC, Tutter AV, Cvetic C, et al. (2002). [Expression error: Missing operand for > "MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts."]. J. Biol. Chem. 277 (36): 33049–57. doi:10.1074/jbc.M204438200. PMID 12087101. 
  • Osaki M, Osaki M, Yamashita H, et al. (2003). [Expression error: Missing operand for > "Expression of minichromosome maintenance-2 in human malignant fibrous histiocytomas: Correlations with Ki-67 and P53 expression, and apoptosis."]. Int. J. Mol. Med. 10 (2): 161–8. PMID 12119552. 

 

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