MCM5
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| MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | MCM5; CDC46; MGC5315; P1-CDC46 | ||||||||||
| External IDs | OMIM: 602696 MGI: 103197 HomoloGene: 4904 GeneCards: MCM5 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 4174 | 17218 | |||||||||
| Ensembl | ENSG00000100297 | ENSMUSG00000005410 | |||||||||
| UniProt | P33992 | Q52KC3 | |||||||||
| RefSeq (mRNA) | NM_006739 | NM_008566 | |||||||||
| RefSeq (protein) | NP_006730 | NP_032592 | |||||||||
| Location (UCSC) | Chr 22: 34.13 - 34.15 Mb | Chr 8: 78.01 - 78.02 Mb | |||||||||
| PubMed search | [1] | [2] | |||||||||
DNA replication licensing factor MCM5 is a protein that in humans is encoded by the MCM5 gene.[1][2][3]
The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.[3]
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See also
Interactions
MCM5 has been shown to interact with ORC2L,[4] MCM7,[4][5][6] STAT1,[7][6] MCM2,[4][6] Cell division cycle 7-related protein kinase,[4] MCM3[4][6] and ORC6L.[4]
References
- ^ Paul R, Hu B, Musahl C, Hameister H, Knippers R (Sep 1996). [Expression error: Missing operand for > "Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5"]. Cytogenet Cell Genet 73 (4): 317–21. PMID 8751386.
- ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). [Expression error: Missing operand for > "The DNA sequence of human chromosome 22"]. Nature 402 (6761): 489–95. doi:. PMID 10591208.
- ^ a b "Entrez Gene: MCM5 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4174.
- ^ a b c d e f Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (Mar. 2003). [Expression error: Missing operand for > "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells"]. J. Mol. Biol. (England) 327 (1): 111–28. ISSN 0022-2836. PMID 12614612.
- ^ Fujita, M; Kiyono T, Hayashi Y, Ishibashi M (Apr. 1997). [Expression error: Missing operand for > "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP"]. J. Biol. Chem. (UNITED STATES) 272 (16): 10928–35. ISSN 0021-9258. PMID 9099751.
- ^ a b c d DaFonseca, C J; Shu F, Zhang J J (Mar. 2001). [Expression error: Missing operand for > "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma"]. Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (6): 3034–9. doi:. ISSN 0027-8424. PMID 11248027.
- ^ Zhang, J J; Zhao Y, Chait B T, Lathem W W, Ritzi M, Knippers R, Darnell J E (Dec. 1998). [Expression error: Missing operand for > "Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation"]. EMBO J. (ENGLAND) 17 (23): 6963–71. doi:. ISSN 0261-4189. PMID 9843502.
Further reading
- Burkhart R, Schulte D, Hu D, et al. (1995). [Expression error: Missing operand for > "Interactions of human nuclear proteins P1Mcm3 and P1Cdc46."]. Eur. J. Biochem. 228 (2): 431–8. doi:. PMID 7705359.
- Maruyama K, Sugano S (1994). [Expression error: Missing operand for > "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides."]. Gene 138 (1-2): 171–4. doi:. PMID 8125298.
- Hu B, Burkhart R, Schulte D, et al. (1994). [Expression error: Missing operand for > "The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins."]. Nucleic Acids Res. 21 (23): 5289–93. doi:. PMID 8265339.
- Ishimi Y, Ichinose S, Omori A, et al. (1996). [Expression error: Missing operand for > "Binding of human minichromosome maintenance proteins with histone H3."]. J. Biol. Chem. 271 (39): 24115–22. doi:. PMID 8798650.
- Fujita M, Kiyono T, Hayashi Y, Ishibashi M (1997). [Expression error: Missing operand for > "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP."]. J. Biol. Chem. 272 (16): 10928–35. doi:. PMID 9099751.
- Tsuruga H, Yabuta N, Hashizume K, et al. (1997). [Expression error: Missing operand for > "Expression, nuclear localization and interactions of human MCM/P1 proteins."]. Biochem. Biophys. Res. Commun. 236 (1): 118–25. doi:. PMID 9223437.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). [Expression error: Missing operand for > "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library."]. Gene 200 (1-2): 149–56. doi:. PMID 9373149.
- Zhang JJ, Zhao Y, Chait BT, et al. (1999). [Expression error: Missing operand for > "Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation."]. Embo J. 17 (23): 6963–71. doi:. PMID 9843502.
- Ohtani K, Iwanaga R, Nakamura M, et al. (1999). [Expression error: Missing operand for > "Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F."]. Oncogene 18 (14): 2299–309. doi:. PMID 10327050.
- DaFonseca CJ, Shu F, Zhang JJ (2001). [Expression error: Missing operand for > "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma."]. Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034–9. doi:. PMID 11248027.
- Going JJ, Keith WN, Neilson L, et al. (2002). [Expression error: Missing operand for > "Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous oesophageal epithelium and Barrett's mucosa."]. Gut 50 (3): 373–7. doi:. PMID 11839717.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Kneissl M, Pütter V, Szalay AA, Grummt F (2003). [Expression error: Missing operand for > "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells."]. J. Mol. Biol. 327 (1): 111–28. doi:. PMID 12614612.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). [Expression error: Missing operand for > "Complete sequencing and characterization of 21,243 full-length human cDNAs."]. Nat. Genet. 36 (1): 40–5. doi:. PMID 14702039.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). [Expression error: Missing operand for > "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway."]. Nat. Cell Biol. 6 (2): 97–105. doi:. PMID 14743216.
- Ramachandran N, Hainsworth E, Bhullar B, et al. (2004). [Expression error: Missing operand for > "Self-assembling protein microarrays."]. Science 305 (5680): 86–90. doi:. PMID 15232106.
- Yu Z, Feng D, Liang C (2004). [Expression error: Missing operand for > "Pairwise interactions of the six human MCM protein subunits."]. J. Mol. Biol. 340 (5): 1197–206. doi:. PMID 15236977.
- Jin J, Smith FD, Stark C, et al. (2004). [Expression error: Missing operand for > "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization."]. Curr. Biol. 14 (16): 1436–50. doi:. PMID 15324660.
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