definição e significado de MT-ATP8

MT-ATP8

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ATP synthase F0 subunit 8

Identifiers

Symbols

ATP8; MTATP8

External IDs

HomoloGene: 48474 GeneCards: ATP8 Gene

Gene ontology
Molecular function	• hydrogen ion transporting ATP synthase activity, rotational mechanism • hydrogen ion transporting ATPase activity, rotational mechanism
Cellular component	• mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) • mitochondrion • membrane • proton-transporting two-sector ATPase complex
Biological process	• ion transport • ATP synthesis coupled proton transport • proton transport

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

NP_536847

n/a

Location (UCSC)

Chr MT:
0.01 - 0.01 Mb

n/a

PubMed search

[1]

n/a

ATP synthase protein 8 is an enzyme that in humans is encoded by the MT-ATP8 gene.

Torroni A, Achilli A, Macaulay V, et al. (2006). [Expression error: Missing operand for > "Harvesting the fruit of the human mtDNA tree."]. Trends Genet. 22 (6): 339–45. doi:10.1016/j.tig.2006.04.001. PMID 16678300.
Bodenteich A, Mitchell LG, Polymeropoulos MH, Merril CR (1993). [Expression error: Missing operand for > "Dinucleotide repeat in the human mitochondrial D-loop."]. Hum. Mol. Genet. 1 (2): 140. doi:10.1093/hmg/1.2.140-a. PMID 1301157.
Lu X, Walker T, MacManus JP, Seligy VL (1992). [Expression error: Missing operand for > "Differentiation of HT-29 human colonic adenocarcinoma cells correlates with increased expression of mitochondrial RNA: effects of trehalose on cell growth and maturation."]. Cancer Res. 52 (13): 3718–25. PMID 1377597.
Marzuki S, Noer AS, Lertrit P, et al. (1992). [Expression error: Missing operand for > "Normal variants of human mitochondrial DNA and translation products: the building of a reference data base."]. Hum. Genet. 88 (2): 139–45. PMID 1757091.
Moraes CT, Andreetta F, Bonilla E, et al. (1991). [Expression error: Missing operand for > "Replication-competent human mitochondrial DNA lacking the heavy-strand promoter region."]. Mol. Cell. Biol. 11 (3): 1631–7. PMID 1996112.
Attardi G, Chomyn A, Doolittle RF, et al. (1987). [Expression error: Missing operand for > "Seven unidentified reading frames of human mitochondrial DNA encode subunits of the respiratory chain NADH dehydrogenase."]. Cold Spring Harb. Symp. Quant. Biol. 51 Pt 1: 103–14. PMID 3472707.
Chomyn A, Cleeter MW, Ragan CI, et al. (1986). [Expression error: Missing operand for > "URF6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunit."]. Science 234 (4776): 614–8. doi:10.1126/science.3764430. PMID 3764430.
Chomyn A, Mariottini P, Cleeter MW, et al. (1985). [Expression error: Missing operand for > "Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase."]. Nature 314 (6012): 592–7. doi:10.1038/314592a0. PMID 3921850.
Anderson S, Bankier AT, Barrell BG, et al. (1981). [Expression error: Missing operand for > "Sequence and organization of the human mitochondrial genome."]. Nature 290 (5806): 457–65. doi:10.1038/290457a0. PMID 7219534.
Montoya J, Ojala D, Attardi G (1981). [Expression error: Missing operand for > "Distinctive features of the 5'-terminal sequences of the human mitochondrial mRNAs."]. Nature 290 (5806): 465–70. doi:10.1038/290465a0. PMID 7219535.
Horai S, Hayasaka K, Kondo R, et al. (1995). [Expression error: Missing operand for > "Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs."]. Proc. Natl. Acad. Sci. U.S.A. 92 (2): 532–6. doi:10.1073/pnas.92.2.532. PMID 7530363.
Rieder MJ, Taylor SL, Tobe VO, Nickerson DA (1998). [Expression error: Missing operand for > "Automating the identification of DNA variations using quality-based fluorescence re-sequencing: analysis of the human mitochondrial genome."]. Nucleic Acids Res. 26 (4): 967–73. doi:10.1093/nar/26.4.967. PMID 9461455.
Andrews RM, Kubacka I, Chinnery PF, et al. (1999). [Expression error: Missing operand for > "Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA."]. Nat. Genet. 23 (2): 147. doi:10.1038/13779. PMID 10508508.
Ingman M, Kaessmann H, Pääbo S, Gyllensten U (2001). [Expression error: Missing operand for > "Mitochondrial genome variation and the origin of modern humans."]. Nature 408 (6813): 708–13. doi:10.1038/35047064. PMID 11130070.
Finnilä S, Lehtonen MS, Majamaa K (2001). [Expression error: Missing operand for > "Phylogenetic network for European mtDNA."]. Am. J. Hum. Genet. 68 (6): 1475–84. doi:10.1086/320591. PMID 11349229.
Maca-Meyer N, González AM, Larruga JM, et al. (2003). [Expression error: Missing operand for > "Major genomic mitochondrial lineages delineate early human expansions."]. BMC Genet. 2: 13. doi:10.1186/1471-2156-2-13. PMID 11553319.
Herrnstadt C, Elson JL, Fahy E, et al. (2002). [Expression error: Missing operand for > "Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups."]. Am. J. Hum. Genet. 70 (5): 1152–71. doi:10.1086/339933. PMID 11938495.
Silva WA, Bonatto SL, Holanda AJ, et al. (2002). [Expression error: Missing operand for > "Mitochondrial genome diversity of Native Americans supports a single early entry of founder populations into America."]. Am. J. Hum. Genet. 71 (1): 187–92. doi:10.1086/341358. PMID 12022039.
Mishmar D, Ruiz-Pesini E, Golik P, et al. (2003). [Expression error: Missing operand for > "Natural selection shaped regional mtDNA variation in humans."]. Proc. Natl. Acad. Sci. U.S.A. 100 (1): 171–6. doi:10.1073/pnas.0136972100. PMID 12509511.
Ingman M, Gyllensten U (2003). [Expression error: Missing operand for > "Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines."]. Genome Res. 13 (7): 1600–6. doi:10.1101/gr.686603. PMID 12840039.

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v • d • e Mitochondrial enzymes and transporters
Outer membrane	fatty acid degradation (Carnitine palmitoyltransferase I, Long fatty acyl CoA synthetase) tryptophan metabolism (Kynureninase) monoamine neurotransmitter metabolism (Monoamine oxidase)
Intermembrane space	Adenylate kinase - Creatine kinase
Inner membrane	oxidative phosphorylation (Coenzyme Q - cytochrome c reductase, Cytochrome c, NADH dehydrogenase, Succinate dehydrogenase) pyrimidine metabolism (Dihydroorotate dehydrogenase) mitochondrial shuttle (Malate-aspartate shuttle, Glycerol phosphate shuttle) other (Glutamate aspartate transporter, Glycerol-3-phosphate dehydrogenase, ATP synthase, Carnitine palmitoyltransferase II, Uncoupling protein)
Matrix	citric acid cycle (Citrate synthase, Aconitase, Isocitrate dehydrogenase, Oxoglutarate dehydrogenase, Succinyl coenzyme A synthetase, Fumarase, Malate dehydrogenase) anaplerotic reactions (Aspartate transaminase, Glutamate dehydrogenase, Pyruvate dehydrogenase complex) urea cycle (Carbamoyl phosphate synthetase I, Ornithine transcarbamylase, N-Acetylglutamate synthase) alcohol metabolism (ALDH2)
Other/to be sorted	steroidogenesis (Cholesterol side-chain cleavage enzyme, Steroid 11-beta-hydroxylase, Aldosterone synthase)
Mitochondrial DNA	Complex I (MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6) - Complex III (MT-CYB) - Complex IV (MT-CO1, MT-CO2, MT-CO3) ATP synthase (MT-ATP6, MT-ATP8) tRNA (MT-TA, MT-TC, MT-TD, MT-TE, MT-TF, MT-TG, MT-TH, MT-TI, MT-TK, MT-TL1, MT-TL2, MT-TM, MT-TN, MT-TP, MT-TQ, MT-TR, MT-TS1, MT-TS2, MT-TT, MT-TV, MT-TW, MT-TY)

Definição e significado de MT-ATP8

Definição

MT-ATP8

From Wikipedia, the free encyclopedia

Further reading