Definição e significado de Omics

The English-language neologism omics informally refers to a field of study in biology ending in -omics, such as genomics, proteomics or metabolomics. The related suffix -ome is used to address the objects of study of such fields, such as the genome, proteome or metabolome respectively.

Functional genomics aims at identifying the functions of as many genes as possible of a given organism. It combines different -omics techniques such as transcriptomics and proteomics with saturated mutant collections.^[1]

The suffix -ome as used in molecular biology refers to a totality of some sort; it is an example of a "neo-suffix" formed by abstraction from various Greek terms in -ωμα, a sequence that does not form an identifiable suffix in Greek.

  Origin

The Oxford English Dictionary (OED) distinguishes three different fields of application for the -ome suffix:

1. in medicine, forming nouns with the sense "swelling, tumour"
2. in botany or zoology, forming nouns in the sense "a part of an animal or plant with a specified structure"
3. in cellular and molecular biology, forming nouns with the sense "all constituents considered collectively".

The -ome suffix originated as a variant of -oma, and became productive in the last quarter of the 19th century. It was originally found in terms like sclerome^[2] or rhizome.^[2] All of these are terms derived from Greek words in -ωμα,^[2] a sequence that is not a single suffix, but analyzable as -ω-μα, the -ω- belonging to the word stem, usually a verb, and the -μα being a genuine Greek suffix forming abstract nouns.

OED suggests that the third definition originated as a back-formation from mitome,^[2] Early attestations include biome (1916)^[3] and genome (first coined as German Genom in 1920^[4]).^[5]

The association with chromosome in molecular biology is by false etymology. The word chromosome derives from the Greek stems χρωμ(ατ)- "colour" and σωμ(ατ)- "body".^[5] While σωμα "body" genuinely contains the -μα suffix, the preceding -ω- is not a stem-forming suffix but part of the word's root. Because genome refers to the complete genetic makeup of an organism, a neo-suffix -ome suggested itself as referring to "wholeness" or "completion".^[6]

Bioinformaticians and molecular biologists figured amongst the first scientists to start to apply the "-ome" suffix widely. Some early advocates were bioinformaticians in Cambridge, UK, where there were many early bioinformatics labs such as the MRC centre, Sanger centre, and EBI (European Bioinformatics Institute). For example, the MRC centre is where the first genome and proteome projects were carried out.

  Kinds of omics studies

  Genomics

• Genomics: Study of the genomes of organisms.
  • Cognitive Genomics: Examines the changes in cognitive processes associated with genetic profiles. Cognitive processes are very important for human behavior. It is about knowledge and the way people use their knowledge.
  • Comparative Genomics: Study of the relationship of genome structure and function across different biological species or strains
  • Functional genomics: Gene and protein functions and interactions (uses microarray kind of techniques)
  • Metagenomics: Study of metagenomes, genetic material recovered directly from environmental samples.
  • Personal genomics: Branch of genomics concerned with the sequencing and analysis of the genome of an individual. Once the genotypes are known, the individual's genotype can be compared with the published literature to determine likelihood of trait expression and disease risk. Helps in Personalized Medicine
• Epigenomics: Study of the complete set of epigenetic modifications on the genetic material of a cell, known as the epigenome. ChIP-Chip and ChIP-Seq technologies used.
• Transcriptomics: The transcriptome is the set of all RNA molecules, including mRNA, rRNA, tRNA, and other non-coding RNA produced in one or a population of cells.

  Proteomics

• Proteomics: Proteome is the entire complement of proteins, including the modifications made to a particular set of proteins, produced by an organism or system. Large-scale study of proteins, particularly their structures and functions. Mass spectrometry techniques are used.
  • Immunoproteomics: study of large sets of proteins (proteomics) involved in the immune response
  • Nutriproteomics: Identifying the molecular targets of nutritive and non-nutritive components of the diet. Uses proteomics mass spectrometry data for protein expression studies
  • Proteogenomics: An emerging field of biological research at the intersection of proteomics and genomics. Proteomics data used for gene annotations.
  • Structural genomics: Study of 3-dimensional structure of every protein encoded by a given genome using a combination of experimental and modeling approaches.

  Metabolism

• Metabolomics: Scientific study of chemical processes involving metabolites. It is a "systematic study of the unique chemical fingerprints that specific cellular processes leave behind", the study of their small-molecule metabolite profiles
• Metabonomics: The quantitative measurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification

  Nutrition, pharmacology, and toxicolgy

• Nutritional genomics: A science studying the relationship between human genome, nutrition and health.
  • Nutrigenetics: studies the effect of genetic variations on the interaction between diet and health with implications to susceptible subgroups
  • Nutrigenomics: Study of the effects of foods and food constituents on gene expression. Studies the effect of nutrients on the genome, proteome, and metabolome
• Pharmacogenomics investigates the effect of the sum of variations within the human genome on drugs;
• Pharmacomicrobiomics investigates the effect of variations within the human microbiome on drugs.
• Toxicogenomics: a field of science that deals with the collection, interpretation, and storage of information about gene and protein activity within particular cell or tissue of an organism in response to toxic substances.

  Miscellaneous

• Psychogenomics: Process of applying the powerful tools of genomics and proteomics to achieve a better understanding of the biological substrates of normal behavior and of diseases of the brain that manifest themselves as behavioral abnormalities. Applying psychogenomics to the study of drug addiction The ultimate goal is to develop more effective treatments for these disorders as well as objective diagnostic tools, preventive measures, and eventually cures.
• Stem cell genomics: Helps in stem cell biology. Aim is to establish stem cells as a leading model system for understanding human biology and disease states and ultimately to accelerate progress toward clinical translation.

  Unrelated words in -omics

The word “comic” does not use the "omics" suffix; it derives from Greek “κωμ(ο)-” (merriment) + “-ικ(ο)-” (an adjectival suffix), rather than presenting a truncation of “σωμ(ατ)-”.

Similarly, the word “economy” is assembled from Greek “οικ(ο)-” (household) + “νομ(ο)-” (law or custom), and “economic(s)” from “οικ(ο)-” + “νομ(ο)-” + “-ικ(ο)-”. The suffix -omics is sometimes used to create portmanteau words to refer to schools of economics such as Reaganomics.

  Current usage

Many “omes” beyond the original “genome” have become useful and have been widely adopted by research scientists. “Proteomics” has become well-established as a term for studying proteins at a large scale. "Omes" can provide an easy short-hand to encapsulate a field; for example, an interactomics study is clearly recognisable as relating to large-scale analyses of gene-gene, protein-protein, or protein-ligand interactions. Researchers are rapidly taking up omes and omics, as shown by the explosion of the use of these terms in PubMed since the mid '90s.^[7]

  Notes

  External links

Look up -omics in Wiktionary, the free dictionary.

• Omics.org, an openfree and comprehensive Omics list on the internet.
• List of omics, including references/origins. Maintained by the (CHI) Cambridge Health Institute.
• Omics World, resources and information for omics research
• Lederberg J, McCray A. 'Ome Sweet 'Omics — A Genealogical Treasury of Words PDF (2 pages). The Scientist 15[7]:8, Apr. 2, 2001. Commentary.