From Wikipedia, the free encyclopedia
DNA primase large subunit is an enzyme that in humans is encoded by the PRIM2 gene.[1][2]
The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.[2]
References
- ^ Shiratori A, Okumura K, Nogami M, Taguchi H, Onozaki T, Inoue T, Ando T, Shibata T, Izumi M, Miyazawa H, et al. (Feb 1996). [Expression error: Missing operand for > "Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12"]. Genomics 28 (2): 350-3. PMID 8530050.
- ^ a b "Entrez Gene: PRIM2A primase, polypeptide 2A, 58kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5558.
Further reading
- Stadlbauer F, Brueckner A, Rehfuess C, et al. (1994). [Expression error: Missing operand for > "DNA replication in vitro by recombinant DNA-polymerase-alpha-primase."]. Eur. J. Biochem. 222 (3): 781–93. doi:10.1111/j.1432-1033.1994.tb18925.x. PMID 8026492.
- Maruyama K, Sugano S (1994). [Expression error: Missing operand for > "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides."]. Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). [Expression error: Missing operand for > "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library."]. Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Coll JM, Hickey RJ, Cronkey EA, et al. (1998). [Expression error: Missing operand for > "Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome."]. Oncol. Res. 9 (11-12): 629–39. PMID 9563011.
- Schneider A, Smith RW, Kautz AR, et al. (1998). [Expression error: Missing operand for > "Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit."]. J. Biol. Chem. 273 (34): 21608–15. doi:10.1074/jbc.273.34.21608. PMID 9705292.
- Arezi B, Kirk BW, Copeland WC, Kuchta RD (1999). [Expression error: Missing operand for > "Interactions of DNA with human DNA primase monitored with photoactivatable cross-linking agents: implications for the role of the p58 subunit."]. Biochemistry 38 (39): 12899–907. doi:10.1021/bi9908991. PMID 10504261.
- Smith RW, Nasheuer HP (2002). [Expression error: Missing operand for > "Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180."]. FEBS Lett. 527 (1-3): 143–6. doi:10.1016/S0014-5793(02)03197-6. PMID 12220650.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). [Expression error: Missing operand for > "The DNA sequence and analysis of human chromosome 6."]. Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). [Expression error: Missing operand for > "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."]. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Rush J, Moritz A, Lee KA, et al. (2005). [Expression error: Missing operand for > "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."]. Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.