From Wikipedia
There are three known prokaryotic release factors involved in the termination of translation.
- RF1 recognize stop codons UAG and UAA.
- RF2 recognize stop codons UGA and UAA.
- RF3 promotes termination by either factor by accelerating dissociation.
The release factors provide the means of termination by having a conformation that mimics that of tRNA molecules. The decoding release factor binds to the A site of the ribosome and directly recognise the stop codon [1]. Once RF1 (or RF2) and RF3 are bound to the ribosome, the polypeptide is released, and the ribosome and release factors dissasemble, thus completing the process of translation [2].
References
- ↑ "Direct recognition of mRNA stop signals by Escherichia coli polypeptide chain release factor two.". http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7806547&dopt=Abstract. Retrieved 2006-11-28.
- ↑ "Mapping Functionally Important Motifs SPF and GGQ of the Decoding Release Factor RF2 to the Escherichia coli Ribosome by Hydroxyl Radical Footprinting.". http://www.jbc.org/cgi/content/abstract/278/17/15095. Retrieved 2006-11-28.
| Protein biosynthesis: translation (prokaryotic, eukaryotic) |
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| Ribosomal proteins | | | | |
Archaeal | aIF1 aIF2 aIF5 aIF6 | |
| eIF1 (AX, AY, 1B) eIF2 (α, β, γ) eIF3 (A, B, C, D, F, G, H, I, J, K, M, S6) eIF4 (A2, A3, B, E1, E2, G1, G2, G3, H) eIF5 (A, A2, B) eIF6 |
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Other | |
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| Other concepts | |
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