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Trans-Splicing (n.)
1.(MeSH)The joining of RNA from two different genes. One type of trans-splicing is the "spliced leader" type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the "discontinuous group II introns" type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.
Trans Splicing (n.)
1.(MeSH)The joining of RNA from two different genes. One type of trans-splicing is the "spliced leader" type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the "discontinuous group II introns" type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.
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Trans Splicing (n.) (MeSH)
G05.315.700.700.750, G06.535.839.700.750, RNA Trans-Splicing (MeSH), Trans RNA Splicing (MeSH), Trans-Splicing (MeSH)
Trans-Splicing (n.) (MeSH)
G05.315.700.700.750, G06.535.839.700.750, RNA Trans-Splicing (MeSH), Trans RNA Splicing (MeSH), Trans Splicing (MeSH)
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Trans-Splicing (n.) [MeSH]
Wikipedia
Trans-splicing is a special form of RNA processing in eukaryotes where exons from two different primary RNA transcripts are joined end to end and ligated.
In contrast "normal" (cis-)splicing processes a single molecule. That is, trans-splicing results in an RNA transcript that came from multiple RNA polymerases on the genome. This phenomenon can be exploited for molecular therapy to address mutated gene products.
Trans-splicing can be the mechanism behind certain oncogenic fusion transcripts.[1][2]
Trans-splicing is used by certain microbial organisms, notably protozoa of the Kinetoplastae class to produce variable surface antigens and change from one life stage to another.
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