definição e significado de Trans-splicing | sensagent.com


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alemão búlgaro chinês croata dinamarquês eslovaco esloveno espanhol estoniano farsi finlandês francês grego hebraico hindi holandês húngaro indonésio inglês islandês italiano japonês korean letão língua árabe lituano malgaxe norueguês polonês português romeno russo sérvio sueco tailandês tcheco turco vietnamês

Definição e significado de Trans-splicing

Definição

Trans-Splicing (n.)

1.(MeSH)The joining of RNA from two different genes. One type of trans-splicing is the "spliced leader" type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the "discontinuous group II introns" type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.

Trans Splicing (n.)

1.(MeSH)The joining of RNA from two different genes. One type of trans-splicing is the "spliced leader" type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the "discontinuous group II introns" type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.

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Trans-splicing

                   

Trans-splicing is a special form of RNA processing in eukaryotes where exons from two different primary RNA transcripts are joined end to end and ligated.

In contrast "normal" (cis-)splicing processes a single molecule. That is, trans-splicing results in an RNA transcript that came from multiple RNA polymerases on the genome. This phenomenon can be exploited for molecular therapy to address mutated gene products.

Trans-splicing can be the mechanism behind certain oncogenic fusion transcripts.[1][2]

Trans-splicing is used by certain microbial organisms, notably protozoa of the Kinetoplastae class to produce variable surface antigens and change from one life stage to another.

  References

  1. ^ Li et al. (2008). "A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells". Science 321 (5894): 1357–61. DOI:10.1126/science.1156725. PMID 18772439 
  2. ^ Rickman et al. (2009). "SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer". Cancer Res. 69 (7): 2734–8. DOI:10.1158/0008-5472.CAN-08-4926. PMID 19293179 
  • Dixon RJ, Eperon IC, Samani NJ (2007). "Complementary intron sequence motifs associated with human exon repetition: a role for intragenic, inter-transcript interactions in gene expression". Bioinformatics 23 (2): 150–5. DOI:10.1093/bioinformatics/btl575. PMID 17105720. 
  • Yang Y, Walsh CE (2005). "Spliceosome-mediated RNA trans-splicing". Mol. Ther. 12 (6): 1006–12. DOI:10.1016/j.ymthe.2005.09.006. PMID 16226059. 
  • Coady TH, Shababi M, Tullis GE, Lorson CL (2007). "Restoration of SMN Function: Delivery of a Trans-splicing RNA Re-directs SMN2 Pre-mRNA Splicing". Molecular Therapy 15 (8): 1471–8. DOI:10.1038/sj.mt.6300222. PMID 17551501. 


   
               

 

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